Baker Bros. Advisors

Baker Bros. Advisors latest Q4_2020 13F filings reported $26,543,637,000 in market value on this 2021-02-16 report date . The portfolio quarterly return is 6.07%. This fund has 126 securities concentrations of 100% weights.

Baker Bros. Advisors largest holding is Seagen Inc. with weight of 31.19% and $8,278,767,000 in market value. The portfolio return is computed based on the amount invested in the new quarter. The following shows the portfolio details.

Portfolio Details

Stock Name	Tickers	Value	Current Value (x1000)	Change Value %	Weights	Computed Price	Shares Change %
AbCellera Biologics Inc.	ABCL	BUY	$420,515	0.000%	1.58%	$40.24	0.000%
Ultragenyx Pharmaceutical Inc.	RARE	BUY	$61,524	0.000%	0.23%	$138.43	0.000%
Aligos Therapeutics Inc.	ALGS	BUY	$44,517	0.000%	0.17%	$27.65	0.000%
Opthea Limited American Depositary Shares	OPT	BUY	$37,107	0.000%	0.14%	$11.21	0.000%
BioAtla Inc.	BCAB	BUY	$28,058	0.000%	0.11%	$34.01	0.000%
Mereo BioPharma Group plc American Depositary Shares	MREO	BUY	$21,588	0.000%	0.08%	$3.58	0.000%
Verastem Inc.	VSTM	BUY	$21,607	0.000%	0.08%	$2.13	0.000%
Chinook Therapeutics Inc.	KDNY	BUY	$11,874	0.000%	0.04%	$15.86	0.000%
Silverback Therapeutics Inc.	SBTX	BUY	$11,033	0.000%	0.04%	$46.34	0.000%
Five Prime Therapeutics Inc.	FPRX	BUY	$11,363	0.000%	0.04%	$17.01	0.000%
Tricida Inc.	TCDA	BUY	$4,437	0.000%	0.02%	$7.05	0.000%
Gossamer Bio Inc.	GOSS	BUY	$4,649	0.000%	0.02%	$9.67	0.000%
MacroGenics Inc.	MGNX	BUY	$4,588	0.000%	0.02%	$22.86	0.000%
LogicBio Therapeutics Inc.	LOGC	BUY	$3,445	0.000%	0.01%	$7.63	0.000%
Sunesis Pharmaceuticals Inc.	SNSS	BUY	$106	0.000%	0.00%	$2.00	0.000%
Seagen Inc.	SGEN	DECR	$8,278,767	-0.105%	31.19%	$175.14	0.000%
BeiGene Ltd. American Depositary Shares	BGNE	DECR	$3,015,126	-0.209%	11.36%	$258.39	-0.123%
Incyte Corp.	INCY	DECR	$2,783,337	-0.031%	10.49%	$86.98	0.000%
Madrigal Pharmaceuticals Inc.	MDGL	DECR	$166,668	-0.064%	0.63%	$111.17	0.000%
Forma Therapeutics Holdings Inc.	FMTX	DECR	$70,668	-0.200%	0.27%	$34.90	0.143%
Insmed Inc.	INSM	DECR	$71,773	-0.017%	0.27%	$33.29	-0.051%
Axsome Therapeutics Inc.	AXSM	DECR	$63,452	-0.072%	0.24%	$81.47	-0.189%
Neurocrine Biosciences Inc.	NBIX	DECR	$64,888	-0.003%	0.24%	$95.85	0.000%
Nurix Therapeutics Inc.	NRIX	DECR	$58,820	-0.058%	0.22%	$32.88	0.000%
ADC Therapeutics SA	ADCT	DECR	$45,394	-0.185%	0.17%	$32.01	-0.160%
Horizon Therapeutics Public Limited Company Ordinary Shares	HZNP	DECR	$43,825	-0.154%	0.17%	$73.15	-0.101%
Global Blood Therapeutics Inc.	GBT	DECR	$39,861	-0.215%	0.15%	$43.31	0.000%
ChemoCentryx Inc.	CCXI	DECR	$40,663	-0.175%	0.15%	$61.92	-0.270%
Protagonist Therapeutics Inc.	PTGX	DECR	$28,954	-0.072%	0.11%	$20.16	-0.100%
Aeglea BioTherapeutics Inc.	AGLE	DECR	$26,838	-0.136%	0.10%	$7.87	-0.221%
Altimmune Inc.	ALT	DECR	$21,257	-0.270%	0.08%	$11.28	-0.146%
Aurinia Pharmaceuticals Inc Ordinary Shares	AUPH	DECR	$19,501	-0.182%	0.07%	$13.83	-0.129%
Novavax Inc.	NVAX	DECR	$18,924	-0.068%	0.07%	$111.51	-0.094%
Invitae Corp.	NVTA	DECR	$16,446	-0.027%	0.06%	$1.60	0.000%
CymaBay Therapeutics Inc.	CBAY	DECR	$16,607	-0.295%	0.06%	$5.74	-0.110%
Albireo Pharma Inc.	ALBO	DECR	$15,472	-0.156%	0.06%	$37.51	-0.249%
GW Pharmaceuticals Plc American Depositary Shares	GWPH	DECR	$13,029	-0.035%	0.05%	$115.41	-0.186%
Assembly Biosciences Inc.	ASMB	DECR	$9,326	-0.632%	0.04%	$6.05	0.000%
bluebird bio Inc.	BLUE	DECR	$9,822	-0.278%	0.04%	$43.27	-0.099%
Vaxart Inc	VXRT	DECR	$7,987	-0.233%	0.03%	$5.71	-0.107%
Harmony Biosciences Holdings Inc.	HRMY	DECR	$6,507	-0.520%	0.02%	$36.15	-0.550%
Burning Rock Biotech Limited American Depositary Shares	BNR	DECR	$4,831	-0.188%	0.02%	$23.10	-0.119%
Ovid Therapeutics Inc.	OVID	DECR	$2,208	-0.349%	0.01%	$2.31	0.618%
Inozyme Pharma Inc.	INZY	DECR	$2,208	-0.291%	0.01%	$20.64	-0.097%
Viking Therapeutics Inc.	VKTX	DECR	$2,049	-0.129%	0.01%	$5.63	-0.100%
Akero Therapeutics Inc.	AKRO	DECR	$3,054	-0.247%	0.01%	$25.80	-0.102%
Arcus Biosciences Inc.	RCUS	DECR	$1,888	-0.046%	0.01%	$25.97	-0.370%
Legend Biotech Corporation American Depositary Shares	LEGN	DECR	$3,256	-0.177%	0.01%	$28.16	-0.098%
Acceleron Pharma Inc.	XLRN	DECR	$2,870	-0.005%	0.01%	$127.95	-0.125%
uniQure N.V. Ordinary Shares	QURE	DECR	$244	-0.966%	0.00%	$36.20	-0.965%
GENFIT S.A. American Depositary Shares	GNFT	DECR	$71	-0.527%	0.00%	$4.82	-0.482%
Adamas Pharmaceuticals Inc.	ADMS	DECR	$641	-0.050%	0.00%	$4.33	-0.097%
Galmed Pharmaceuticals Ltd. Ordinary Shares	GLMD	DECR	$575	-0.207%	0.00%	$3.11	-0.100%
Evofem Biosciences Inc.	EVFM	DECR	$991	-0.030%	0.00%	$2.41	-0.050%
Bellicum Pharmaceuticals Inc.	BLCM	DECR	$879	-0.463%	0.00%	$3.53	0.000%
Kezar Life Sciences Inc.	KZR	DECR	$729	-0.738%	0.00%	$5.22	-0.757%
Oyster Point Pharma Inc.	OYST	DECR	$1,156	-0.197%	0.00%	$18.82	-0.100%
Molecular Templates Inc.	MTEM	DECR	$1,257	-0.226%	0.00%	$9.39	-0.101%
Galapagos NV American Depositary Shares	GLPG	DECR	$1,107	-0.371%	0.00%	$99.02	-0.099%
ACADIA Pharmaceuticals Inc.	ACAD	INCR	$2,240,219	0.296%	8.44%	$53.46	0.000%
Kodiak Sciences Inc	KOD	INCR	$2,039,104	1.788%	7.68%	$146.91	0.124%
Alexion Pharmaceuticals Inc.	ALXN	INCR	$1,368,786	0.365%	5.16%	$156.24	0.000%
Prelude Therapeutics Incorporated	PRLD	INCR	$723,988	1.375%	2.73%	$71.55	0.000%
BioMarin Pharmaceutical Inc.	BMRN	INCR	$665,505	0.153%	2.51%	$87.69	0.000%
Invitae Corp.	NVTA	INCR	$654,292	0.274%	2.46%	$41.81	0.320%
Ascendis Pharma A/S American Depositary Shares	ASND	INCR	$590,446	0.081%	2.22%	$166.78	0.000%
Mirati Therapeutics Inc.	MRTX	INCR	$309,645	0.323%	1.17%	$219.64	0.000%
argenx SE American Depositary Shares	ARGX	INCR	$299,842	0.120%	1.13%	$294.09	0.000%
IGM Biosciences Inc.	IGMS	INCR	$277,663	0.196%	1.05%	$88.29	0.000%
Amarin Corporation plc	AMRN	INCR	$136,880	0.015%	0.52%	$4.89	-0.126%
Heron Therapeutics Inc.	HRTX	INCR	$126,878	0.428%	0.48%	$21.17	0.000%
Kymera Therapeutics Inc.	KYMR	INCR	$121,471	0.919%	0.46%	$62.00	0.000%
Allakos Inc.	ALLK	INCR	$99,995	0.758%	0.38%	$140.00	0.023%
Cerus Corp.	CERS	INCR	$94,895	0.105%	0.36%	$6.92	0.000%
BioCryst Pharmaceuticals Inc.	BCRX	INCR	$94,584	1.169%	0.36%	$7.45	0.000%
Pacific Biosciences of California Inc.	PACB	INCR	$83,059	1.589%	0.31%	$25.94	-0.015%
Zymeworks Inc.	ZYME	INCR	$80,742	0.015%	0.30%	$47.26	0.000%
Rhythm Pharmaceuticals Inc.	RYTM	INCR	$68,821	0.285%	0.26%	$29.73	-0.063%
Atreca Inc. Class A	BCEL	INCR	$57,054	0.156%	0.21%	$16.15	0.000%
Adaptimmune Therapeutics plc American Depositary Shares	ADAP	INCR	$52,988	0.049%	0.20%	$5.39	0.553%
Neoleukin Therapeutics Inc.	NLTX	INCR	$53,887	0.175%	0.20%	$14.10	0.000%
Kiniksa Pharmaceuticals Ltd. Class A	KNSA	INCR	$49,469	0.153%	0.19%	$17.67	0.000%
Apellis Pharmaceuticals Inc.	APLS	INCR	$51,283	0.896%	0.19%	$57.20	0.000%
Krystal Biotech Inc.	KRYS	INCR	$41,932	0.257%	0.16%	$60.00	-0.098%
DBV Technologies S.A. American Depositary Shares	DBVT	INCR	$38,289	0.514%	0.14%	$2.62	0.000%
Merus N.V.	MRUS	INCR	$35,717	0.461%	0.13%	$17.53	0.000%
Alkermes plc Ordinary Shares	ALKS	INCR	$30,626	0.360%	0.12%	$19.95	0.130%
Frequency Therapeutics Inc.	FREQ	INCR	$30,200	0.656%	0.11%	$35.26	-0.098%
Reata Pharmaceuticals Inc. Class A	RETA	INCR	$27,688	4.344%	0.10%	$123.62	3.211%
Athira Pharma Inc.	ATHA	INCR	$27,618	0.696%	0.10%	$34.25	-0.086%
Fulgent Genetics Inc.	FLGT	INCR	$25,819	0.181%	0.10%	$52.10	-0.093%
Adaptive Biotechnologies Corp.	ADPT	INCR	$22,451	0.048%	0.08%	$59.13	-0.138%
Immatics N.V. Ordinary Shares	IMTX	INCR	$19,476	0.833%	0.07%	$10.79	0.802%
Idera Pharmaceuticals Inc.	IDRA	INCR	$16,914	0.715%	0.06%	$3.67	0.000%
BioMarin Pharmaceutical Inc.	BMRN	INCR	$16,033	0.024%	0.06%	$1.07	0.000%
Xencor Inc.	XNCR	INCR	$16,116	0.013%	0.06%	$43.63	-0.099%
Sangamo Therapeutics Inc.	SGMO	INCR	$13,379	0.491%	0.05%	$15.61	-0.097%
Gamida Cell Ltd. Ordinary Shares	GMDA	INCR	$12,990	3.943%	0.05%	$8.39	1.445%
Xenon Pharmaceuticals Inc.	XENE	INCR	$10,572	0.256%	0.04%	$15.38	-0.096%
IVERIC bio Inc.	ISEE	INCR	$9,716	0.225%	0.04%	$6.91	0.000%
Mirum Pharmaceuticals Inc.	MIRM	INCR	$11,302	0.061%	0.04%	$17.46	0.171%
Syros Pharmaceuticals Inc.	SYRS	INCR	$7,488	0.227%	0.03%	$10.85	0.000%
AnaptysBio Inc.	ANAB	INCR	$9,184	0.278%	0.03%	$21.50	-0.123%
Autolus Therapeutics plc American Depositary Share	AUTL	INCR	$6,993	0.302%	0.03%	$8.94	0.696%
Karuna Therapeutics Inc.	KRTX	INCR	$7,108	0.182%	0.03%	$101.59	-0.100%
Crinetics Pharmaceuticals Inc.	CRNX	INCR	$8,699	0.836%	0.03%	$14.11	1.039%
Denali Therapeutics Inc.	DNLI	INCR	$7,433	1.087%	0.03%	$83.76	-0.107%
HOOKIPA Pharma Inc.	HOOK	INCR	$7,768	0.171%	0.03%	$11.09	0.000%
Cabaletta Bio Inc.	CABA	INCR	$7,942	0.151%	0.03%	$12.48	0.000%
Passage Bio Inc.	PASG	INCR	$6,018	0.758%	0.02%	$25.57	-0.098%
Genetron Holdings Limited ADS	GTH	INCR	$6,374	4.338%	0.02%	$14.00	3.553%
Replimune Group Inc.	REPL	INCR	$5,856	0.231%	0.02%	$38.15	-0.257%
iTeos Therapeutics Inc.	ITOS	INCR	$5,085	0.230%	0.02%	$33.82	-0.103%
Protara Therapeutics Inc.	TARA	INCR	$4,834	0.439%	0.02%	$24.21	0.000%
Intellia Therapeutics Inc.	NTLA	INCR	$6,055	1.492%	0.02%	$54.40	-0.090%
InflaRx N.V.	IFRX	INCR	$4,307	0.003%	0.02%	$5.03	-0.150%
Orchard Therapeutics plc American Depositary Shares	ORTX	INCR	$1,436	0.018%	0.01%	$4.32	-0.031%
Constellation Pharmaceuticals Inc.	CNST	INCR	$3,304	0.223%	0.01%	$28.80	-0.139%
NGM Biopharmaceuticals Inc.	NGM	INCR	$3,230	0.719%	0.01%	$30.30	-0.097%
Chiasma Inc.	CHMA	INCR	$3,228	0.012%	0.01%	$4.35	0.000%
Alector Inc.	ALEC	INCR	$3,620	0.294%	0.01%	$15.13	-0.099%
Dicerna Pharmaceuticals Inc.	DRNA	INCR	$2,250	0.106%	0.01%	$22.03	-0.097%
TCR2 Therapeutics Inc.	TCRR	INCR	$3,430	0.378%	0.01%	$30.93	-0.095%
Infinity Pharmaceuticals Inc.	INFI	INCR	$1,107	0.630%	0.00%	$2.12	-0.100%
Leap Therapeutics Inc.	LPTX	INCR	$1,259	0.136%	0.00%	$2.25	0.000%
Affimed N.V.	AFMD	INCR	$958	0.490%	0.00%	$5.82	-0.133%
Urovant Sciences Ltd.	UROV	SOLD	$0	0.000%	-100.00%	$0.00	0.000%
Sunesis Pharmaceuticals Inc.	SNSS	SOLD	$0	0.000%	-100.00%	$0.00	0.000%
MyoKardia, Inc.	MYOK	SOLD	$0	0.000%	-100.00%	$0.00	0.000%
Immunomedics Inc	IMMU	SOLD	$0	0.000%	-100.00%	$0.00	0.000%
Exact Sciences Corp.	EXAS	SOLD	$0	0.000%	-100.00%	$0.00	0.000%
Catalyst Pharmaceuticals Inc.	CPRX	SOLD	$0	0.000%	-100.00%	$0.00	0.000%
Aravive Inc.	ARAV	SOLD	$0	0.000%	-100.00%	$0.00	0.000%
Applied Therapeutics Inc.	APLT	SOLD	$0	0.000%	-100.00%	$0.00	0.000%
Neurocrine Biosciences Inc.	NBIX	SOLD	$0	0.000%	-100.00%	$0.00	0.000%