Baker Bros. Advisors

Baker Bros. Advisors latest Q4_2020 13F filings reported $26,543,637,000 in market value on this 2021-02-16 report date . The portfolio quarterly return is 6.07%. This fund has 126 securities concentrations of 100% weights.

Baker Bros. Advisors largest holding is Seagen Inc. with weight of 31.19% and $8,278,767,000 in market value. The portfolio return is computed based on the amount invested in the new quarter. The following shows the portfolio details.

Portfolio Details

Stock NameTickersValueCurrent Value (x1000)Change Value %WeightsComputed PriceShares Change %
AbCellera Biologics Inc.ABCLBUY$420,5150.000%1.58%$40.240.000%
Ultragenyx Pharmaceutical Inc.RAREBUY$61,5240.000%0.23%$138.430.000%
Aligos Therapeutics Inc.ALGSBUY$44,5170.000%0.17%$27.650.000%
Opthea Limited American Depositary SharesOPTBUY$37,1070.000%0.14%$11.210.000%
BioAtla Inc.BCABBUY$28,0580.000%0.11%$34.010.000%
Mereo BioPharma Group plc American Depositary SharesMREOBUY$21,5880.000%0.08%$3.580.000%
Verastem Inc.VSTMBUY$21,6070.000%0.08%$2.130.000%
Chinook Therapeutics Inc.KDNYBUY$11,8740.000%0.04%$15.860.000%
Silverback Therapeutics Inc.SBTXBUY$11,0330.000%0.04%$46.340.000%
Five Prime Therapeutics Inc.FPRXBUY$11,3630.000%0.04%$17.010.000%
Tricida Inc.TCDABUY$4,4370.000%0.02%$7.050.000%
Gossamer Bio Inc.GOSSBUY$4,6490.000%0.02%$9.670.000%
MacroGenics Inc.MGNXBUY$4,5880.000%0.02%$22.860.000%
LogicBio Therapeutics Inc.LOGCBUY$3,4450.000%0.01%$7.630.000%
Sunesis Pharmaceuticals Inc.SNSSBUY$1060.000%0.00%$2.000.000%
Seagen Inc.SGENDECR$8,278,767-0.105%31.19%$175.140.000%
BeiGene Ltd. American Depositary SharesBGNEDECR$3,015,126-0.209%11.36%$258.39-0.123%
Incyte Corp.INCYDECR$2,783,337-0.031%10.49%$86.980.000%
Madrigal Pharmaceuticals Inc.MDGLDECR$166,668-0.064%0.63%$111.170.000%
Forma Therapeutics Holdings Inc.FMTXDECR$70,668-0.200%0.27%$34.900.143%
Insmed Inc.INSMDECR$71,773-0.017%0.27%$33.29-0.051%
Axsome Therapeutics Inc.AXSMDECR$63,452-0.072%0.24%$81.47-0.189%
Neurocrine Biosciences Inc.NBIXDECR$64,888-0.003%0.24%$95.850.000%
Nurix Therapeutics Inc.NRIXDECR$58,820-0.058%0.22%$32.880.000%
ADC Therapeutics SAADCTDECR$45,394-0.185%0.17%$32.01-0.160%
Horizon Therapeutics Public Limited Company Ordinary SharesHZNPDECR$43,825-0.154%0.17%$73.15-0.101%
Global Blood Therapeutics Inc.GBTDECR$39,861-0.215%0.15%$43.310.000%
ChemoCentryx Inc.CCXIDECR$40,663-0.175%0.15%$61.92-0.270%
Protagonist Therapeutics Inc.PTGXDECR$28,954-0.072%0.11%$20.16-0.100%
Aeglea BioTherapeutics Inc.AGLEDECR$26,838-0.136%0.10%$7.87-0.221%
Altimmune Inc.ALTDECR$21,257-0.270%0.08%$11.28-0.146%
Aurinia Pharmaceuticals Inc Ordinary SharesAUPHDECR$19,501-0.182%0.07%$13.83-0.129%
Novavax Inc.NVAXDECR$18,924-0.068%0.07%$111.51-0.094%
Invitae Corp.NVTADECR$16,446-0.027%0.06%$1.600.000%
CymaBay Therapeutics Inc.CBAYDECR$16,607-0.295%0.06%$5.74-0.110%
Albireo Pharma Inc.ALBODECR$15,472-0.156%0.06%$37.51-0.249%
GW Pharmaceuticals Plc American Depositary SharesGWPHDECR$13,029-0.035%0.05%$115.41-0.186%
Assembly Biosciences Inc.ASMBDECR$9,326-0.632%0.04%$6.050.000%
bluebird bio Inc.BLUEDECR$9,822-0.278%0.04%$43.27-0.099%
Vaxart IncVXRTDECR$7,987-0.233%0.03%$5.71-0.107%
Harmony Biosciences Holdings Inc.HRMYDECR$6,507-0.520%0.02%$36.15-0.550%
Burning Rock Biotech Limited American Depositary SharesBNRDECR$4,831-0.188%0.02%$23.10-0.119%
Ovid Therapeutics Inc.OVIDDECR$2,208-0.349%0.01%$2.310.618%
Inozyme Pharma Inc.INZYDECR$2,208-0.291%0.01%$20.64-0.097%
Viking Therapeutics Inc.VKTXDECR$2,049-0.129%0.01%$5.63-0.100%
Akero Therapeutics Inc.AKRODECR$3,054-0.247%0.01%$25.80-0.102%
Arcus Biosciences Inc.RCUSDECR$1,888-0.046%0.01%$25.97-0.370%
Legend Biotech Corporation American Depositary SharesLEGNDECR$3,256-0.177%0.01%$28.16-0.098%
Acceleron Pharma Inc.XLRNDECR$2,870-0.005%0.01%$127.95-0.125%
uniQure N.V. Ordinary SharesQUREDECR$244-0.966%0.00%$36.20-0.965%
GENFIT S.A. American Depositary SharesGNFTDECR$71-0.527%0.00%$4.82-0.482%
Adamas Pharmaceuticals Inc.ADMSDECR$641-0.050%0.00%$4.33-0.097%
Galmed Pharmaceuticals Ltd. Ordinary SharesGLMDDECR$575-0.207%0.00%$3.11-0.100%
Evofem Biosciences Inc.EVFMDECR$991-0.030%0.00%$2.41-0.050%
Bellicum Pharmaceuticals Inc.BLCMDECR$879-0.463%0.00%$3.530.000%
Kezar Life Sciences Inc.KZRDECR$729-0.738%0.00%$5.22-0.757%
Oyster Point Pharma Inc.OYSTDECR$1,156-0.197%0.00%$18.82-0.100%
Molecular Templates Inc.MTEMDECR$1,257-0.226%0.00%$9.39-0.101%
Galapagos NV American Depositary SharesGLPGDECR$1,107-0.371%0.00%$99.02-0.099%
ACADIA Pharmaceuticals Inc.ACADINCR$2,240,2190.296%8.44%$53.460.000%
Kodiak Sciences IncKODINCR$2,039,1041.788%7.68%$146.910.124%
Alexion Pharmaceuticals Inc.ALXNINCR$1,368,7860.365%5.16%$156.240.000%
Prelude Therapeutics IncorporatedPRLDINCR$723,9881.375%2.73%$71.550.000%
BioMarin Pharmaceutical Inc.BMRNINCR$665,5050.153%2.51%$87.690.000%
Invitae Corp.NVTAINCR$654,2920.274%2.46%$41.810.320%
Ascendis Pharma A/S American Depositary SharesASNDINCR$590,4460.081%2.22%$166.780.000%
Mirati Therapeutics Inc.MRTXINCR$309,6450.323%1.17%$219.640.000%
argenx SE American Depositary SharesARGXINCR$299,8420.120%1.13%$294.090.000%
IGM Biosciences Inc.IGMSINCR$277,6630.196%1.05%$88.290.000%
Amarin Corporation plcAMRNINCR$136,8800.015%0.52%$4.89-0.126%
Heron Therapeutics Inc.HRTXINCR$126,8780.428%0.48%$21.170.000%
Kymera Therapeutics Inc.KYMRINCR$121,4710.919%0.46%$62.000.000%
Allakos Inc.ALLKINCR$99,9950.758%0.38%$140.000.023%
Cerus Corp.CERSINCR$94,8950.105%0.36%$6.920.000%
BioCryst Pharmaceuticals Inc.BCRXINCR$94,5841.169%0.36%$7.450.000%
Pacific Biosciences of California Inc.PACBINCR$83,0591.589%0.31%$25.94-0.015%
Zymeworks Inc.ZYMEINCR$80,7420.015%0.30%$47.260.000%
Rhythm Pharmaceuticals Inc.RYTMINCR$68,8210.285%0.26%$29.73-0.063%
Atreca Inc. Class ABCELINCR$57,0540.156%0.21%$16.150.000%
Adaptimmune Therapeutics plc American Depositary SharesADAPINCR$52,9880.049%0.20%$5.390.553%
Neoleukin Therapeutics Inc.NLTXINCR$53,8870.175%0.20%$14.100.000%
Kiniksa Pharmaceuticals Ltd. Class AKNSAINCR$49,4690.153%0.19%$17.670.000%
Apellis Pharmaceuticals Inc.APLSINCR$51,2830.896%0.19%$57.200.000%
Krystal Biotech Inc.KRYSINCR$41,9320.257%0.16%$60.00-0.098%
DBV Technologies S.A. American Depositary SharesDBVTINCR$38,2890.514%0.14%$2.620.000%
Merus N.V.MRUSINCR$35,7170.461%0.13%$17.530.000%
Alkermes plc Ordinary SharesALKSINCR$30,6260.360%0.12%$19.950.130%
Frequency Therapeutics Inc.FREQINCR$30,2000.656%0.11%$35.26-0.098%
Reata Pharmaceuticals Inc. Class ARETAINCR$27,6884.344%0.10%$123.623.211%
Athira Pharma Inc.ATHAINCR$27,6180.696%0.10%$34.25-0.086%
Fulgent Genetics Inc.FLGTINCR$25,8190.181%0.10%$52.10-0.093%
Adaptive Biotechnologies Corp.ADPTINCR$22,4510.048%0.08%$59.13-0.138%
Immatics N.V. Ordinary SharesIMTXINCR$19,4760.833%0.07%$10.790.802%
Idera Pharmaceuticals Inc.IDRAINCR$16,9140.715%0.06%$3.670.000%
BioMarin Pharmaceutical Inc.BMRNINCR$16,0330.024%0.06%$1.070.000%
Xencor Inc.XNCRINCR$16,1160.013%0.06%$43.63-0.099%
Sangamo Therapeutics Inc.SGMOINCR$13,3790.491%0.05%$15.61-0.097%
Gamida Cell Ltd. Ordinary SharesGMDAINCR$12,9903.943%0.05%$8.391.445%
Xenon Pharmaceuticals Inc.XENEINCR$10,5720.256%0.04%$15.38-0.096%
IVERIC bio Inc.ISEEINCR$9,7160.225%0.04%$6.910.000%
Mirum Pharmaceuticals Inc.MIRMINCR$11,3020.061%0.04%$17.460.171%
Syros Pharmaceuticals Inc.SYRSINCR$7,4880.227%0.03%$10.850.000%
AnaptysBio Inc.ANABINCR$9,1840.278%0.03%$21.50-0.123%
Autolus Therapeutics plc American Depositary ShareAUTLINCR$6,9930.302%0.03%$8.940.696%
Karuna Therapeutics Inc.KRTXINCR$7,1080.182%0.03%$101.59-0.100%
Crinetics Pharmaceuticals Inc.CRNXINCR$8,6990.836%0.03%$14.111.039%
Denali Therapeutics Inc. DNLIINCR$7,4331.087%0.03%$83.76-0.107%
HOOKIPA Pharma Inc.HOOKINCR$7,7680.171%0.03%$11.090.000%
Cabaletta Bio Inc.CABAINCR$7,9420.151%0.03%$12.480.000%
Passage Bio Inc.PASGINCR$6,0180.758%0.02%$25.57-0.098%
Genetron Holdings Limited ADSGTHINCR$6,3744.338%0.02%$14.003.553%
Replimune Group Inc.REPLINCR$5,8560.231%0.02%$38.15-0.257%
iTeos Therapeutics Inc.ITOSINCR$5,0850.230%0.02%$33.82-0.103%
Protara Therapeutics Inc.TARAINCR$4,8340.439%0.02%$24.210.000%
Intellia Therapeutics Inc.NTLAINCR$6,0551.492%0.02%$54.40-0.090%
InflaRx N.V.IFRXINCR$4,3070.003%0.02%$5.03-0.150%
Orchard Therapeutics plc American Depositary SharesORTXINCR$1,4360.018%0.01%$4.32-0.031%
Constellation Pharmaceuticals Inc.CNSTINCR$3,3040.223%0.01%$28.80-0.139%
NGM Biopharmaceuticals Inc.NGMINCR$3,2300.719%0.01%$30.30-0.097%
Chiasma Inc.CHMAINCR$3,2280.012%0.01%$4.350.000%
Alector Inc.ALECINCR$3,6200.294%0.01%$15.13-0.099%
Dicerna Pharmaceuticals Inc. DRNAINCR$2,2500.106%0.01%$22.03-0.097%
TCR2 Therapeutics Inc.TCRRINCR$3,4300.378%0.01%$30.93-0.095%
Infinity Pharmaceuticals Inc.INFIINCR$1,1070.630%0.00%$2.12-0.100%
Leap Therapeutics Inc.LPTXINCR$1,2590.136%0.00%$2.250.000%
Affimed N.V.AFMDINCR$9580.490%0.00%$5.82-0.133%
Urovant Sciences Ltd.UROVSOLD$00.000%-100.00%$0.000.000%
Sunesis Pharmaceuticals Inc.SNSSSOLD$00.000%-100.00%$0.000.000%
MyoKardia, Inc.MYOKSOLD$00.000%-100.00%$0.000.000%
Immunomedics IncIMMUSOLD$00.000%-100.00%$0.000.000%
Exact Sciences Corp.EXASSOLD$00.000%-100.00%$0.000.000%
Catalyst Pharmaceuticals Inc.CPRXSOLD$00.000%-100.00%$0.000.000%
Aravive Inc.ARAVSOLD$00.000%-100.00%$0.000.000%
Applied Therapeutics Inc.APLTSOLD$00.000%-100.00%$0.000.000%
Neurocrine Biosciences Inc.NBIXSOLD$00.000%-100.00%$0.000.000%