Baker Bros. Advisors

Baker Bros. Advisors latest Q4_2020 13F filings reported $26,543,637,000 in market value on this 2021-02-16 report date . The portfolio quarterly return is 6.07%. This fund has 126 securities concentrations of 100% weights.

Baker Bros. Advisors largest holding is Seagen Inc. with weight of 31.19% and $8,278,767,000 in market value. The portfolio return is computed based on the amount invested in the new quarter. The following shows the portfolio details.

Portfolio Performance History

FILE DATEREPORT PERIODQTR YEARFILE TYPENOS. OF STOCKSREPORTED VALUERETURN
2021-02-162020-12-31Q4_202013F-HR126$26,543,637,0006.07%
2020-11-162020-09-30Q3_202013F-HR120$25,025,928,00010.39%
2020-08-142020-06-30Q2_202013F-HR114$22,670,991,00039.63%
2020-05-152020-03-31Q1_202013F-HR110$16,236,233,000-13.68%
2020-02-142019-12-31Q4_201913F-HR99$18,809,854,00027.96%
2019-11-142019-09-30Q3_201913F-HR109$14,699,689,000-0.10%
2019-08-142019-06-30Q2_201913F-HR103$14,714,211,000-5.81%
2019-05-152019-03-31Q1_201913F-HR96$15,621,759,00027.92%
2019-02-132018-12-31Q4_201813F-HR93$12,212,527,000-19.55%
2018-11-142018-09-30Q3_201813F-HR97$15,181,170,00014.07%
2018-08-142018-06-30Q2_201813F-HR119$13,308,803,00012.81%
2018-05-152018-03-31Q1_201813F-HR114$11,797,988,0002.26%
2018-02-142017-12-31Q4_201713F-HR123$11,537,077,000-6.44%
2017-11-142017-09-30Q3_201713F-HR121$12,330,918,0007.80%
2017-08-142017-06-30Q2_201713F-HR120$11,438,426,000-6.40%
2017-05-152017-03-31Q1_201713F-HR119$12,220,691,00019.80%
2017-02-142016-12-31Q4_201613F-HR133$10,200,965,000-7.43%
2016-11-142016-09-30Q3_201613F-HR134$11,019,928,00015.54%
2016-08-152016-06-30Q2_201613F-HR135$9,537,918,0000.59%

Portfolio Details

Stock NameTickersValueCurrent Value (x1000)Change Value %WeightComputed PriceShares Change %Current Shares
SEAGEN INCSGENDECR$8,278,767-10.50%31.19%$175.140.00%47,269,424
BEIGENE LTDBGNEDECR$3,015,126-20.87%11.36%$258.39-112.27%11,668,897
INCYTE CORPINCYDECR$2,783,337-3.07%10.49%$86.98-100.00%31,999,741
ACADIA PHARMACEUTICALS INCACADINCR$2,240,21929.60%8.44%$53.46-100.00%41,904,586
KODIAK SCIENCES INCKODINCR$2,039,104178.81%7.68%$146.91-87.63%13,879,952
ALEXION PHARMACEUTICALS INCALXNINCR$1,368,78636.54%5.16%$156.24-100.00%8,760,794
PRELUDE THERAPEUTICS INCPRLDINCR$723,988137.47%2.73%$71.55-100.00%10,118,636
BIOMARIN PHARMACEUTICAL INCBMRNINCR$665,50515.26%2.51%$87.69-100.00%7,589,294
INVITAE CORPNVTAINCR$654,29227.36%2.46%$41.81-67.95%15,649,182
ASCENDIS PHARMA A/S - ADR 1 ORDASNDINCR$590,4468.07%2.22%$166.78-100.00%3,540,270
ABCELLERA BIOLOGICS INCABCLBUY$420,5150.00%1.58%$40.240.00%10,450,180
MIRATI THERAPEUTICS INCMRTXINCR$309,64532.27%1.17%$219.64-100.00%1,409,784
ARGENX SE - ADR 1 ORDARGXINCR$299,84212.03%1.13%$294.09-100.00%1,019,557
IGM BIOSCIENCES INCIGMSINCR$277,66319.63%1.05%$88.29-99.99%3,144,892
MADRIGAL PHARMACEUTICALS INCMDGLDECR$166,668-6.37%0.63%$111.170.00%1,499,213
AMARIN CORP PLCAMRNINCR$136,8801.54%0.52%$4.89-112.58%27,991,761
HERON THERAPEUTICS INCHRTXINCR$126,87842.81%0.48%$21.17-100.00%5,994,704
KYMERA THERAPEUTICS INCKYMRINCR$121,47191.89%0.46%$62.00-100.00%1,959,211
ALLAKOS INCALLKINCR$99,99575.77%0.38%$140.00-97.74%714,250
BIOCRYST PHARMACEUTICALS INCBCRXINCR$94,584116.89%0.36%$7.45-100.00%12,695,818
CERUS CORPCERSINCR$94,89510.54%0.36%$6.92-100.00%13,713,195
PACIFIC BIOSCIENCES CALIF INPACBINCR$83,059158.93%0.31%$25.94-101.48%3,201,972
ZYMEWORKS INCZYMEINCR$80,7421.46%0.30%$47.26-100.00%1,708,472
FORMA THERAPEUTICS HLDGS INCFMTXDECR$70,668-19.96%0.27%$34.90-85.70%2,024,876
INSMED INCINSMDECR$71,773-1.74%0.27%$33.29-105.14%2,156,001
RHYTHM PHARMACEUTICALS INCRYTMINCR$68,82128.52%0.26%$29.73-106.32%2,314,873
AXSOME THERAPEUTICS INCAXSMDECR$63,452-7.21%0.24%$81.47-118.85%778,834
NEUROCRINE BIOSCIENCES INCNBIXDECR$64,888-0.32%0.24%$95.850.00%676,975
ULTRAGENYX PHARMACEUTICAL INRAREBUY$61,5240.00%0.23%$138.430.00%444,444
NURIX THERAPEUTICS INCNRIXDECR$58,820-5.81%0.22%$32.880.00%1,788,921
ATRECA INCBCELINCR$57,05415.60%0.21%$16.15-100.00%3,532,760
ADAPTIMMUNE THERAPEUTICS PLCADAPINCR$52,9884.89%0.20%$5.39-44.70%9,830,877
NEOLEUKIN THERAPEUTICS INCNLTXINCR$53,88717.50%0.20%$14.10-100.00%3,821,740
APELLIS PHARMACEUTICALS INCAPLSINCR$51,28389.59%0.19%$57.20-100.00%896,551
KINIKSA PHARMACEUTICALS LTDKNSAINCR$49,46915.34%0.19%$17.67-100.00%2,799,577
ADC THERAPEUTICS SAADCTDECR$45,394-18.46%0.17%$32.01-115.96%1,418,107
ALIGOS THERAPEUTICS INCALGSBUY$44,5170.00%0.17%$27.650.00%1,610,000
HORIZON THERAPEUTICS PUB LHZNPDECR$43,825-15.35%0.17%$73.15-110.11%599,110
KRYSTAL BIOTECH INCKRYSINCR$41,93225.65%0.16%$60.00-109.85%698,874
CHEMOCENTRYX INCCCXIDECR$40,663-17.54%0.15%$61.92-127.02%656,710
GLOBAL BLOOD THERAPEUTICS INGBTDECR$39,861-21.45%0.15%$43.310.00%920,375
DBV TECHNOLOGIES S ADBVTINCR$38,28951.44%0.14%$2.62-100.00%14,614,264
OPTHEA LTDOPTBUY$37,1070.00%0.14%$11.210.00%3,308,705
Merus N.V.MRUSINCR$35,71746.08%0.13%$17.53-100.00%2,037,469
ALKERMES PLCALKSINCR$30,62636.00%0.12%$19.95-87.04%1,535,149
BIOATLA INCBCABBUY$28,0580.00%0.11%$34.010.00%825,000
FREQUENCY THERAPEUTICS INCFREQINCR$30,20065.56%0.11%$35.26-109.80%856,507
PROTAGONIST THERAPEUTICS INCPTGXDECR$28,954-7.22%0.11%$20.16-110.02%1,436,192
AEGLEA BIOTHERAPEUTICS INCAGLEDECR$26,838-13.57%0.10%$7.87-122.14%3,410,106
ATHIRA PHARMA INCATHAINCR$27,61869.56%0.10%$34.25-108.61%806,367
FULGENT GENETICS INCFLGTINCR$25,81918.06%0.10%$52.10-109.27%495,573
REATA PHARMACEUTICALS INCRETAINCR$27,688434.41%0.10%$123.62221.14%223,976
ADAPTIVE BIOTECHNOLOGIES CORADPTINCR$22,4514.80%0.08%$59.13-113.81%379,682
ALTIMMUNE INCALTDECR$21,257-27.03%0.08%$11.28-114.61%1,884,451
MEREO BIOPHARMA GROUP PLCMREOBUY$21,5880.00%0.08%$3.580.00%6,030,293
VERASTEM INCVSTMBUY$21,6070.00%0.08%$2.130.00%10,144,039
AURINIA PHARMACEUTICALS INCAUPHDECR$19,501-18.18%0.07%$13.83-112.85%1,410,064
IMMATICS N.VIMTXINCR$19,47683.30%0.07%$10.79-19.75%1,805,025
NOVAVAX INCNVAXDECR$18,924-6.79%0.07%$111.51-109.43%169,706
ALBIREO PHARMA INCALBODECR$15,472-15.56%0.06%$37.51-124.88%412,466
BIOMARIN PHARMACEUTICAL INCLSFIXINCR$16,0332.45%0.06%$1.07-100.00%15,000,000
CYMABAY THERAPEUTICS INCCBAYDECR$16,607-29.48%0.06%$5.74-111.05%2,893,276
IDERA PHARMACEUTICALS INCIDRAINCR$16,91471.49%0.06%$3.67-100.00%4,608,786
INVITAE CORPFCVTDECR$16,446-2.72%0.06%$1.600.00%10,300,000
XENCOR INCXNCRINCR$16,1161.30%0.06%$43.63-109.94%369,370
GW PHARMACEUTICALS PLCGWPHDECR$13,029-3.54%0.05%$115.41-118.63%112,897
GAMIDA CELL LTDGMDAINCR$12,990394.29%0.05%$8.3944.47%1,548,314
SANGAMO THERAPEUTICS INCSGMOINCR$13,37949.05%0.05%$15.61-109.74%857,339
ASSEMBLY BIOSCIENCES INCASMBDECR$9,326-63.20%0.04%$6.050.00%1,541,418
CHINOOK THERAPEUTICS INCKDNYBUY$11,8740.00%0.04%$15.860.00%748,693
FIVE PRIME THERAPEUTICS INCFPRXBUY$11,3630.00%0.04%$17.010.00%668,000
IVERIC BIO INCISEEINCR$9,71622.52%0.04%$6.91-100.00%1,406,037
MIRUM PHARMACEUTICALS INCMIRMINCR$11,3026.06%0.04%$17.46-82.95%647,313
SILVERBACK THERAPEUTICS INCORPORATED USD0.0001SBTXBUY$11,0330.00%0.04%$46.340.00%238,095
XENON PHARMACEUTICALS INCXENEINCR$10,57225.60%0.04%$15.38-109.59%687,386
BLUEBIRD BIO INCBLUEDECR$9,822-27.75%0.04%$43.27-109.93%226,988
ANAPTYSBIO INCANABINCR$9,18427.79%0.03%$21.50-112.33%427,179
AUTOLUS THERAPEUTICS PLC 1 ORDAUTLINCR$6,99330.22%0.03%$8.94-30.45%782,183
CABALETTA BIO INCCABAINCR$7,94215.13%0.03%$12.48-100.00%636,363
CRINETICS PHARMACEUTICALS INCRNXINCR$8,69983.64%0.03%$14.113.93%616,520
DENALI THERAPEUTICS INCDNLIINCR$7,433108.67%0.03%$83.76-110.73%88,738
HOOKIPA PHARMA INCHOOKINCR$7,76817.09%0.03%$11.09-100.00%700,481
KARUNA THERAPEUTICS INCKRTXINCR$7,10818.19%0.03%$101.59-110.04%69,966
SYROS PHARMACEUTICALS INCSYRSINCR$7,48822.73%0.03%$10.85-100.00%690,167
VAXART INCVXRTDECR$7,987-23.31%0.03%$5.71-110.68%1,398,795
BURNING ROCK BIOTECH LTDBNRDECR$4,831-18.82%0.02%$23.10-111.87%209,131
GENETRON HLDGS LTDGTHINCR$6,374433.84%0.02%$14.00255.31%455,306
GOSSAMER BIO INCGOSSBUY$4,6490.00%0.02%$9.670.00%480,729
HARMONY BIOSCIENCES HLDGS INHRMYDECR$6,507-52.01%0.02%$36.15-155.00%180,000
INFLARX NVIFRXINCR$4,3070.35%0.02%$5.03-115.02%856,228
INTELLIA THERAPEUTICS INCNTLAINCR$6,055149.18%0.02%$54.40-108.95%111,296
iTeos Therapeutics, Inc.ITOSINCR$5,08523.00%0.02%$33.82-110.27%150,346
MACROGENICS MGNXBUY$4,5880.00%0.02%$22.860.00%200,679
PASSAGE BIO INCPASGINCR$6,01875.81%0.02%$25.57-109.85%235,362
PROTARA THERAPEUTICS INCTARAINCR$4,83443.87%0.02%$24.21-100.00%199,671
REPLIMUNE GROUP INC USD0.001000REPLINCR$5,85623.13%0.02%$38.15-125.69%153,512
TRICIDA INCTCDABUY$4,4370.00%0.02%$7.050.00%629,300
ACCELERON PHARMA INCXLRNDECR$2,870-0.52%0.01%$127.95-112.52%22,430
AKERO THERAPEUTICS INCAKRODECR$3,054-24.74%0.01%$25.80-110.18%118,378
ALECTOR INCALECINCR$3,62029.38%0.01%$15.13-109.93%239,228
ARCUS BIOSCIENCES INCRCUSDECR$1,888-4.55%0.01%$25.97-137.01%72,709
CHIASMA INCCHMAINCR$3,2281.16%0.01%$4.35-100.00%742,133
CONSTELLATION PHARMCETICLS ICNSTINCR$3,30422.33%0.01%$28.80-113.95%114,735
DICERNA PHARMACEUTICALS INC COMMON STOCK USD0.0001DRNAINCR$2,25010.57%0.01%$22.03-109.74%102,121
INOZYME PHARMA INCINZYDECR$2,208-29.12%0.01%$20.64-109.71%106,999
LEGEND BIOTECH CORPLEGNDECR$3,256-17.74%0.01%$28.16-109.81%115,626
LOGICBIO THERAPEUTICS INCLOGCBUY$3,4450.00%0.01%$7.630.00%451,478
NGM BIOPHARMACEUTICALS INCNGMINCR$3,23071.90%0.01%$30.30-109.72%106,616
ORCHARD THERAPEUTICS PLCORTXINCR$1,4361.77%0.01%$4.32-103.12%332,502
OVID THERAPEUTICS INCOVIDDECR$2,208-34.89%0.01%$2.31-38.23%955,690
TCR2 THERAPEUTICS INCTCRRINCR$3,43037.75%0.01%$30.93-109.50%110,888
VIKING THERAPEUTICS INCVKTXDECR$2,049-12.88%0.01%$5.63-109.95%363,980
ADAMAS PHARMACEUTICALS INCADMSDECR$641-5.04%0.00%$4.33-109.66%147,996
AFFIMED N VAFMDINCR$95848.99%0.00%$5.82-113.27%164,605
BELLICUM PHARMACEUTICALS COMBLCMDECR$879-46.30%0.00%$3.530.00%249,123
EVOFEM BIOSCIENCES INCEVFMDECR$991-3.03%0.00%$2.41-105.00%411,396
GALAPAGOS NV SPON ADRGLPGDECR$1,107-37.14%0.00%$99.02-109.93%11,180
GALMED PHARMACEUTICALS LTDGLMDDECR$575-20.69%0.00%$3.11-109.96%184,927
GENFIT S AGNFTDECR$71-52.67%0.00%$4.82-148.16%14,720
INFINITY PHARMACEUTICALS INCINFIINCR$1,10763.03%0.00%$2.12-110.00%522,360
KEZAR LIFE SCIENCES INCKZRDECR$729-73.81%0.00%$5.22-175.71%139,676
LEAP THERAPEUTICS INCLPTXINCR$1,25913.63%0.00%$2.25-100.00%559,705
MOLECULAR TEMPLATES INC COMMTEMDECR$1,257-22.65%0.00%$9.39-110.07%133,833
OYSTER PT PHARMA INCOYSTDECR$1,156-19.72%0.00%$18.82-109.97%61,424
SUNESIS PHARMACEUTICALS INCSNSSBUY$1060.00%0.00%$2.000.00%53,066
UNIQURE NVQUREDECR$244-96.59%0.00%$36.20-196.53%6,740
APPLIED THERAPEUTICS INCAPLTSOLD$00.00%-100.00%$0.000.00%0
ARAVIVE INCARAVSOLD$00.00%-100.00%$0.000.00%0
CATALYST PHARMACEUTICALS INC COMMON STOCK USD0.001CPRXSOLD$00.00%-100.00%$0.000.00%0
EXACT SCIENCES CORPEXASSOLD$00.00%-100.00%$0.000.00%0
IMMUNOMEDICS INCIMMUSOLD$00.00%-100.00%$0.000.00%0
MYOKARDIA INCMYOKSOLD$00.00%-100.00%$0.000.00%0
SUNESIS PHARMACEUTICALS INCSNSSSOLD$00.00%-100.00%$0.000.00%0
UROVANT SCIENCES LTDUROVSOLD$00.00%-100.00%$0.000.00%0
Neurocrine Biosciences Inc 2.250000 05/15/2024SOLD$00.00%-100.00%$0.000.00%0