ORBIMED ADVISORS LLC

ORBIMED ADVISORS LLC latest Q4_2020 13F filings reported $11,418,286,000 in market value on this 2021-02-16 report date . The portfolio quarterly return is 44.29%. This fund has 147 securities concentrations of 100% weights.

ORBIMED ADVISORS LLC largest holding is Prelude Therapeutics Incorporated with weight of 9.77% and $1,115,813,000 in market value. The portfolio return is computed based on the amount invested in the new quarter. The following shows the portfolio details.

Portfolio Performance History

FILE DATEREPORT PERIODQTR YEARFILE TYPENOS. OF STOCKSREPORTED VALUERETURN
2021-02-162020-12-31Q4_202013F-HR147$11,418,286,00044.29%
2020-11-162020-09-30Q3_202013F-HR140$7,913,651,00011.87%
2020-08-142020-06-30Q2_202013F-HR131$7,073,666,00019.73%
2020-05-152020-03-31Q1_202013F-HR138$5,907,868,000-15.39%
2020-02-142019-12-31Q4_201913F-HR132$6,982,618,00033.83%
2019-11-142019-09-30Q3_201913F-HR108$5,217,455,000-17.67%
2019-08-142019-06-30Q2_201913F-HR119$6,337,467,000-0.66%
2019-05-152019-03-31Q1_201913F-HR117$6,379,424,00019.07%
2019-02-142018-12-31Q4_201813F-HR125$5,357,529,000-35.23%
2018-11-142018-09-30Q3_201813F-HR146$8,271,730,000-0.65%
2018-08-142018-06-30Q2_201813F-HR140$8,326,062,0003.96%
2018-05-152018-03-31Q1_201813F-HR130$8,008,642,0001.62%
2018-02-142017-12-31Q4_201713F-HR130$7,881,289,000-24.27%
2017-11-142017-09-30Q3_201713F-HR136$10,406,942,0009.53%
2017-08-142017-06-30Q2_201713F-HR134$9,501,767,0008.13%
2017-05-152017-03-31Q1_201713F-HR131$8,787,228,00012.77%
2017-02-142016-12-31Q4_201613F-HR128$7,792,388,000-10.52%
2016-11-142016-09-30Q3_201613F-HR134$8,708,170,000-8.14%
2016-08-152016-06-30Q2_201613F-HR132$9,480,103,0000.07%

Portfolio Details

Stock NameTickersValueCurrent Value (x1000)Change Value %WeightComputed PriceShares Change %Current Shares
PRELUDE THERAPEUTICS INCPRLDINCR$1,115,813137.47%9.77%$71.55-100.00%15,594,877
SPRINGWORKS THERAPEUTICS INCSWTXINCR$537,10552.13%4.70%$72.52-100.00%7,406,307
PMV PHARMACEUTICALS INCPMVPINCR$450,89473.27%3.95%$61.51-100.00%7,330,423
SILVERBACK THERAPEUTICS INCORPORATED USD0.0001SBTXBUY$405,0530.00%3.55%$46.340.00%8,740,887
ABCELLERA BIOLOGICS INCABCLBUY$338,0470.00%2.96%$40.240.00%8,400,768
TURNING POINT THERAPEUTICS ITPTXINCR$334,51839.48%2.93%$121.85-100.00%2,745,327
PREVAIL THERAPEUTICS INCPRVLINCR$318,884126.62%2.79%$23.07-100.00%13,822,463
IOVANCE BIOTHERAPEUTICS INCIOVAINCR$308,33340.95%2.70%$46.40-100.00%6,645,100
MIRATI THERAPEUTICS INCMRTXINCR$251,55415.03%2.20%$219.64-113.04%1,145,300
BOSTON SCIENTIFIC CORPBSXINCR$234,50226.61%2.05%$35.95-65.43%6,523,000
BRISTOL MYERS SQUIBB COBMYINCR$220,1512.89%1.93%$62.03-100.00%3,549,100
HORIZON THERAPEUTICS PUB LHZNPDECR$220,090-5.83%1.93%$73.150.00%3,008,755
MERCK & CO INC NEWMRKINCR$217,5311.29%1.91%$81.80-97.29%2,659,300
NATERA INCNTRAINCR$210,05737.76%1.84%$99.52-100.00%2,110,700
VERTEX PHARMACEUTICALS INCVRTXINCR$197,1318.76%1.73%$236.34-74.78%834,100
PASSAGE BIO INCPASGINCR$178,04195.04%1.56%$25.57-100.00%6,962,899
ARCUTIS BIOTHERAPEUTICS INCARQTINCR$170,85724.76%1.50%$28.13-70.05%6,073,850
ACUTUS MED INCAFIBDECR$157,820-3.32%1.38%$28.810.00%5,477,958
KINNATE BIOPHARMA INCKNTEBUY$153,0710.00%1.34%$39.780.00%3,847,929
UNITEDHEALTH GROUP INCUNHBUY$136,8700.00%1.20%$350.680.00%390,300
PFIZER COMPANY INCPFEBUY$133,1270.00%1.17%$36.810.00%3,616,600
BIOGEN INCBIIBDECR$129,629-36.17%1.14%$244.86-126.05%529,400
GRAYBUG VISION INCGRAYINCR$129,889128.32%1.14%$29.02-100.00%4,475,847
NEUROCRINE BIOSCIENCES INCNBIXDECR$124,769-0.32%1.09%$95.850.00%1,301,715
CENTENE CORP DELCNCINCR$119,68253.61%1.05%$60.03-50.74%1,993,700
KEROS THERAPEUTICS INCKROSINCR$118,46682.89%1.04%$70.54-100.00%1,679,417
HUMANA INCHUMINCR$117,3781.18%1.03%$410.27-97.93%286,100
Repare Therapeutics, Inc.RPTXINCR$117,52311.47%1.03%$34.30-100.00%3,426,325
THERAVANCE BIOPHARMA INCTBPHINCR$110,51420.19%0.97%$17.77-100.00%6,219,110
NANOSTRING TECHNOLOGIES INCNSTGINCR$108,807105.74%0.95%$66.88-62.49%1,626,900
DEXCOM INCDXCMINCR$103,18910.56%0.90%$369.72-76.72%279,100
ANTHEM INC USD 0.01ANTMBUY$99,6980.00%0.87%$321.090.00%310,500
ORIC PHARMACEUTICALS INCORICINCR$98,90935.35%0.87%$33.85-100.00%2,921,967
AGIOS PHARMACEUTICALS INCAGIOINCR$95,64323.80%0.84%$43.33-100.00%2,207,321
BURNING ROCK BIOTECH LTDBNRDECR$96,135-19.24%0.84%$23.10-112.31%4,161,675
ADICET BIO INC ACETINCR$94,25518.17%0.83%$14.05-100.00%6,708,507
EDWARDS LIFESCIENCES CORPORATIONEWINCR$93,58465.95%0.82%$91.23-54.81%1,025,800
ABBVIE INCABBVINCR$92,395127.34%0.81%$107.15-14.16%862,300
INTUITIVE SURGICAL INCISRGINCR$92,28215.30%0.81%$818.10-100.00%112,800
89BIO INCETNBDECR$90,887-5.03%0.80%$24.370.00%3,729,442
SAREPTA THERAPEUTICS INCSRPTINCR$91,90221.40%0.80%$170.49-100.00%539,049
XTANT MED HLDGS INCXTNTINCR$87,0801043.08%0.76%$1.20587.17%72,803,072
SINOVAC BIOTECH LTDSVAINCR$72,000163.74%0.63%$25.36-100.00%2,839,500
PROGYNY INC USD0.000100PGNYINCR$71,02444.04%0.62%$42.39-100.00%1,675,500
CRISPR THERAPEUTICS AGCRSPINCR$69,17531.28%0.61%$153.11-128.29%451,800
GUARDANT HEALTH INCGHINCR$69,363302.15%0.61%$128.88148.80%538,200
ATRICURE INCATRCINCR$68,37339.52%0.60%$55.67-100.00%1,228,189
TRICIDA INCTCDADECR$67,781-22.18%0.59%$7.050.00%9,614,280
AURINIA PHARMACEUTICALS INCAUPHDECR$65,748-6.11%0.58%$13.830.00%4,754,000
LOGICBIO THERAPEUTICS INCLOGCINCR$64,60210.02%0.57%$7.63-69.07%8,466,783
DECIPHERA PHARMACEUTICALS INDCPHINCR$64,24411.25%0.56%$57.07-100.00%1,125,700
MEIRAGTX HLDGS PLCMGTXINCR$62,11826.33%0.54%$15.14-89.52%4,102,925
IMARA INCIMRAINCR$59,9748.41%0.53%$22.05-100.00%2,719,902
ADVERUM BIOTECHNOLOGIES INCADVMINCR$59,63226.29%0.52%$10.84-80.00%5,501,144
EHEALTH INCEHTHINCR$59,59818.14%0.52%$70.61-67.82%844,046
CHANGE HEALTHCARE INCCHNGINCR$57,69828.53%0.51%$18.65-100.00%3,093,700
STRYKER CORPORATIONSYKINCR$57,58417.60%0.50%$245.04-100.00%235,000
ARCTURUS THERAPEUTICS HLDGSARCTINCR$55,530109.26%0.49%$43.386.94%1,280,086
ASCENDIS PHARMA A/S - ADR 1 ORDASNDDECR$56,121-50.49%0.49%$166.78-154.19%336,500
ACADIA HEALTHCARE COMPANY INACHCINCR$52,02758.36%0.46%$50.26-107.12%1,035,160
GALECTO INCGLTOBUY$51,1780.00%0.45%$12.510.00%4,090,937
THERMO FISHER SCIENTIFIC INCTMOINCR$51,3765.49%0.45%$465.78-100.00%110,300
MEREO BIOPHARMA GROUP PLCMREOBUY$49,4630.00%0.43%$3.580.00%13,816,488
TELA BIO INCTELADECR$45,534-9.07%0.40%$15.040.00%3,027,542
TRILLIUM THERAPEUTICS INCTRILINCR$43,545144.65%0.38%$14.7136.32%2,960,200
ATHENEX INCATNXDECR$40,856-15.12%0.36%$11.06-107.14%3,694,061
SI BONE INCSIBNINCR$40,91826.05%0.36%$29.90-100.00%1,368,500
VERONA PHARMA PLCVRNAINCR$39,86412.18%0.35%$7.00-100.00%5,694,841
ALPINE IMMUNE SCIENCES INCALPNINCR$38,69419.91%0.34%$12.60-116.34%3,070,955
APPLIED THERAPEUTICS INCAPLTINCR$38,99821.46%0.34%$22.01-85.44%1,771,831
CRINETICS PHARMACEUTICALS INCRNXDECR$38,853-9.95%0.34%$14.110.00%2,753,567
XENON PHARMACEUTICALS INCXENEINCR$38,41838.93%0.34%$15.38-100.00%2,497,917
FUSION PHARMACEUTICALS INCFUSNDECR$37,891-2.25%0.33%$11.750.00%3,224,770
KALA PHARMACEUTICALS INCKALADECR$37,053-9.60%0.32%$6.780.00%5,465,030
APTOSE BIOSCIENCES FAPTOINCR$35,171553.13%0.31%$4.38694.67%8,030,000
CURIS INCCRISINCR$35,7622361.25%0.31%$8.19151.71%4,366,494
UNIQURE NVQUREDECR$35,013-1.90%0.31%$36.130.00%969,079
MOLINA HEALTHCARE INCMOHBUY$34,5390.00%0.30%$212.680.00%162,400
ALECTOR INCALECINCR$33,60217.04%0.29%$15.10-118.35%2,225,313
AEGLEA BIOTHERAPEUTICS INCAGLEINCR$31,60211.00%0.28%$7.87-100.00%4,015,524
CTI BIOPHARMA CORPCTICINCR$30,65649.77%0.27%$3.22-100.00%9,520,600
HARPOON THERAPEUTICS INCHARPDECR$30,491-2.24%0.27%$16.610.00%1,835,704
OLEMA PHARMACEUTICALS INCOLMABUY$31,3000.00%0.27%$48.080.00%650,992
NEXTCURE INCNXTCINCR$29,55023.86%0.26%$10.90-100.00%2,711,013
I MABIMABINCR$28,5760.26%0.25%$47.15-100.00%606,070
OAK STREET HEALTH INCORPORATED USD0.001OSHINCR$27,40653.36%0.24%$61.16-66.00%448,100
ALEXION PHARMACEUTICALS INCALXNDECR$26,405-89.44%0.23%$156.24-192.26%169,000
FLEXION THERAPEUTICS INCFLXNINCR$26,63551.94%0.23%$11.54-62.94%2,308,083
SYNDAX PHARMACEUTICALS INCSNDXINCR$26,04161.25%0.23%$22.24-92.98%1,170,900
HERON THERAPEUTICS INCHRTXINCR$25,22542.81%0.22%$21.16-100.00%1,191,846
SCPHARMACEUTICALS INCSCPHDECR$25,377-28.99%0.22%$5.290.00%4,797,148
CORVUS PHARMACEUTICALS INCCRVSDECR$24,093-11.22%0.21%$3.560.00%6,767,584
SIERRA ONCOLOGY INCSRRAINCR$23,68150.23%0.21%$16.03-100.00%1,477,320
ALCON AGALCINCR$23,35717.11%0.20%$66.47-100.00%351,380
FLUIDIGM CORP DELFLDMDECR$23,354-11.55%0.20%$6.00-90.47%3,892,346
9 METERS BIOPHARMA INCNMTRINCR$22,0917.82%0.19%$0.86-100.00%25,716,755
PANDION THERAPEUTICS INCPANDINCR$21,99229.58%0.19%$14.85-100.00%1,480,940
PROTHENA CORP PLCPRTADECR$21,587-39.04%0.19%$12.01-149.29%1,797,458
AMGENAMGNDECR$21,038-9.54%0.18%$229.920.00%91,500
MERSANA THERAPEUTICS INCMRSNDECR$20,579-16.83%0.18%$26.61-141.80%773,348
OTONOMY INCOTICINCR$21,02859.75%0.18%$6.47-100.00%3,250,000
CHINOOK THERAPEUTICS INCKDNYBUY$19,8250.00%0.17%$15.860.00%1,250,001
LARIMAR THERAPEUTICS INCLRMRINCR$18,98141.13%0.17%$21.41-100.00%886,560
TEVA PHARMACEUTICAL INDS LTDTEVAINCR$18,6757.11%0.16%$9.65-100.00%1,935,200
COMPASS PATHWAYS PLCCMPSINCR$16,67436.50%0.15%$47.64-100.00%350,000
MILESTONE PHARMACEUTICALS ININCR$16,704491.50%0.15%$6.70446.23%2,493,109
SYROS PHARMACEUTICALS INCSYRSBUY$16,9530.00%0.15%$10.850.00%1,562,500
VAXCYTE INCPCVXDECR$16,746-47.07%0.15%$26.57-101.64%630,260
VERRICA PHARMACEUTICALS INCVRCAINCR$17,03248.71%0.15%$11.51-100.00%1,479,733
IMMUNOGEN INCIMGNBUY$16,4730.00%0.14%$6.450.00%2,553,900
BIOMX INCINCR$14,7600.63%0.13%$6.38-100.00%2,313,489
RELAY THERAPEUTICS INCRLAYDECR$14,546-2.42%0.13%$41.560.00%350,000
VISTAGEN THERAPEUTICS INCVTGNBUY$14,5500.00%0.13%$1.940.00%7,500,000
ZYMEWORKS INCZYMEDECR$14,982-5.71%0.13%$47.26-107.07%317,002
ACADIA PHARMACEUTICALS INCACADINCR$14,208221.88%0.12%$53.4648.39%265,772
PRAXIS PRECISION MEDICINES IPRAXBUY$14,0630.00%0.12%$55.020.00%255,600
ALX ONCOLOGY HLDGS INCALXOBUY$12,9300.00%0.11%$86.200.00%150,000
BELLUS HEALTH INC NEWBLUINCR$12,5737.20%0.11%$3.00-118.45%4,189,593
AVROBIO INCAVROINCR$11,0647.06%0.10%$13.94-100.00%793,712
GILEAD SCIENCES INCGILDDECR$11,198-7.80%0.10%$58.260.00%192,200
PROTARA THERAPEUTICS INCTARAINCR$10,89543.85%0.10%$24.21-100.00%450,000
NURIX THERAPEUTICS INCNRIXDECR$9,864-5.81%0.09%$32.880.00%300,000
VIATRIS INC NPVVTRSBUY$10,0290.00%0.09%$18.740.00%535,149
PULMONX CORPLUNGBUY$8,6280.00%0.08%$69.020.00%125,000
HEALTH CATALYST INC USD0.001000HCATINCR$7,81818.94%0.07%$43.53-100.00%179,598
INOZYME PHARMA INCINZYDECR$8,264-21.50%0.07%$20.640.00%400,400
NANOBIOTIX SANBTXBUY$8,2500.00%0.07%$16.500.00%500,000
STRONGBRIDGE BIOPHARMA PLCSBBPINCR$8,47915.71%0.07%$2.43-100.00%3,489,369
SUTRO BIOPHARMA INCSTROBUY$7,5990.00%0.07%$21.710.00%350,000
TCR2 THERAPEUTICS INCTCRRBUY$7,7100.00%0.07%$30.930.00%249,279
COGENT BIOSCIENCES INCCOGTBUY$7,3560.00%0.06%$11.230.00%655,000
DYNE THERAPEUTICS INCDYNINCR$7,3504.00%0.06%$21.00-100.00%350,000
HEALTH SCIENCES ACQ CORP 2HSAQINCR$6,40516.45%0.06%$12.81-100.00%500,000
OUTSET MED INCOMINCR$7,10513.68%0.06%$56.84-100.00%125,000
X4 PHARMACEUTICALS INCXFORDECR$6,986-5.03%0.06%$6.430.00%1,086,493
4D MOLECULAR THERAPEUTICS INFDMTBUY$5,1810.00%0.05%$41.450.00%125,000
AKOUOS INCDECR$6,246-13.30%0.05%$19.830.00%315,000
ESSA PHARMA INCDECR$5,494-32.38%0.05%$11.93-160.89%460,500
AERPIO PHARMACEUTICALS INCARPODECR$5,090-34.67%0.04%$0.980.00%5,193,946
SYNLOGIC INCSYBXINCR$4,3856.93%0.04%$2.16-100.00%2,029,996
FORTE BIOSCIENCES INCFBRXDECR$3,357-79.68%0.03%$36.41-172.92%92,200
908 DEVICES INCMASSBUY$2,2780.00%0.02%$56.950.00%40,000
INFLARX NVIFRXDECR$2,797-3.25%0.02%$5.03-118.05%556,025
NOVUS THERAPEUTICS INCBUY$1,1050.00%0.01%$15.000.00%73,650
PURPLE BIOTECH LTDPPBTBUY$1,3190.00%0.01%$3.810.00%346,197
SELECTA BIOSCIENCES INCSELBDECR$1,634-68.53%0.01%$3.03-174.25%539,169
BRISTOL-MYERS SQUIBB COBMYDECR$276-69.33%0.00%$0.690.00%400,000
ACCELERON PHARMA INCXLRNSOLD$00.00%-100.00%$0.000.00%0
ALBIREO PHARMA INCALBOSOLD$00.00%-100.00%$0.000.00%0
ANAPTYSBIO INCANABSOLD$00.00%-100.00%$0.000.00%0
ANNEXON INCANNXSOLD$00.00%-100.00%$0.000.00%0
ARENA PHARMACEUTICALS INCORPORATED COMMON STOCK USD0.0001ARNASOLD$00.00%-100.00%$0.000.00%0
AVIDITY BIOSCIENCES INCRNASOLD$00.00%-100.00%$0.000.00%0
BIOLINERX LTDBLRXSOLD$00.00%-100.00%$0.000.00%0
CALLIDITAS THERAPEUTICS ABCALTSOLD$00.00%-100.00%$0.000.00%0
CELLDEX THERAPEUTICS INC NEWCLDXSOLD$00.00%-100.00%$0.000.00%0
EXELIXIS INCEXELSOLD$00.00%-100.00%$0.000.00%0
IVERIC BIO INCISEESOLD$00.00%-100.00%$0.000.00%0
KITOV PHARMA LTD SPONSORD ADS NEWSOLD$00.00%-100.00%$0.000.00%0
KYMERA THERAPEUTICS INCKYMRSOLD$00.00%-100.00%$0.000.00%0
MYOVANT SCIENCES LTDMYOVSOLD$00.00%-100.00%$0.000.00%0
NABRIVA THERAPEUTICS PLCSOLD$00.00%-100.00%$0.000.00%0
NOVO-NORDISK A SNVOSOLD$00.00%-100.00%$0.000.00%0
NOVUS THERAPEUTICS INCSOLD$00.00%-100.00%$0.000.00%0
OBSEVA SAOBSVSOLD$00.00%-100.00%$0.000.00%0
ROCKET PHARMACEUTICALS INCRCKTSOLD$00.00%-100.00%$0.000.00%0